Southwest High School, South West High School, or Southwestern High School can refer to:
- Southwest High School (El Centro, California), El Centro, California
- Southwest Senior High School, San Diego, California
- Southwest Magnet High School, Macon, Georgia
- Southwest High School (Minneapolis)
- Southwest Miami Senior High School, Miami, Florida
- Southwest Early College Campus, Kansas City, Missouri
- Southwest R-1 School District, Ludlow, Missouri
- Southwest High School (Washburn, Missouri), Washburn, Missouri
- Lincoln Southwest High School, Lincoln, Nebraska
- Southwest Guilford High School (North Carolina), High Point, North Carolina
- Southwest High School (Jacksonville, North Carolina), Jacksonville, North Carolina
- Southwest High School (Fort Worth, Texas)
- Southwest High School (San Antonio, Texas), San Antonio, Texas
- Green Bay Southwest High School, Green Bay, Wisconsin
- Southwestern High School (Piasa, Illinois), Piasa, Illinois
- Southwestern High School (Hanover, Indiana)
- Southwestern High School (Shelbyville, Indiana)
- Southwestern High School (Kentucky), Somerset, Kentucky
- Southwestern Senior High School (Baltimore, Maryland)
- Southwestern High School (Michigan), Detroit, Michigan
- Southwestern High School (New York), West Ellicott, Jamestown, New York
- South Western High School (Hanover, Pennsylvania), Hanover, Pennsylvania
