Nicholas Burns may refer to:
- R. Nicholas Burns (born 1956), former US Under Secretary of State for Political Affairs
- Nicholas Burns (actor) (born 1977), British actorli>
- Nick Burns, a character in the Saturday Night Live sketch, "Nick Burns, Your Company's Computer Guy"
- Nick Burns, a human in the animated series Challenge of the GoBots
See also
- Nicholas Burne, Scottish Catholic controversialist
- Nicholas Byrne (disambiguation)