Collagenous Colitis - Collagenous Colitis Diet

Collagenous colitis is an inflammatory bowel disease affecting the colon specifically with peak incidence in the 5th decade of life, affecting women more than men. Its clinical presentation involves watery diarrhea in the absence of rectal bleeding. It is often classified under the umbrella entity microscopic colitis, that it shares with a related condition, lymphocytic colitis.

Signs and symptoms

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Microscopic colitis causes chronic watery diarrhea with greater than 10 bowel movements per day. Some patients report nocturnal diarrhea, abdominal pain, urgency, fecal incontinence, fatigue, dehydration and weight loss. Patients report a significantly diminished quality of life.

Causes

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The cause of collagenous colitis is unknown.

Diagnosis

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On colonoscopy, the mucosa of the colon typically looks normal, but biopsies of affected tissue usually show deposition of collagen in the lamina propria, which is the area of connective tissue between colonic glands. Radiological tests, such as a barium enema are also typically normal.

Treatment

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Treatment of collagenous colitis is often challenging. Typically, one or more of the following therapeutic agents are used:

• Bismuth agents, including Pepto-Bismol
• 5-aminosalicylic acid
• Budesonide
• Immunosuppressants, including azathioprine
• Corticosteroids

Pilot-scale studies have shown some evidence of possible benefit for both Boswellia serrata extract and specific strains of probiotics in the treatment of collegenous colitis, although larger sample sizes are needed to confirm the results.

See also

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• Colitis
• Lymphocytic colitis
• Inflammatory bowel disease
• Ulcerative colitis

References

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Personal experience with collagenous colitis

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• Chande N, Driman DK, Reynolds RP (March 2005). "Collagenous colitis and lymphocytic colitis: patient characteristics and clinical presentation". Scand. J. Gastroenterol. 40 (3): 343â€"7. PMID 15932175. doi:10.1080/00365520510011623. 
• Yen E. F.; Pardi D. S. (May 2011). "Microscopic Colitis â€" Lymphocytic, Collagenous and ‘Mast Cell’ Colitis". Alimentary Pharmacology & Therapeutics. 34 (1): 21â€"32. doi:10.1111/j.1365-2036.2011.04686.x. 
• Majores Michael; Wunsch Steffen; Blume Bernd; Fischer Hans-Peter & Reichel Christoph (October 2011). "Mucosal Atrophy in Collagenous Colitis: A Case Report". 11 (114). doi:10.1186/1471-230X-11-114. 
• Milman Nataliya; Kraa Gunnar (2010). "NSAID-induced Collagenous Colitis". The Journal of Rheumatology. 37 (11): 2432â€"243. doi:10.3899/jrheum.100573. 

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